TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

摘要: // Kun Wang 1,2,* , Tiantian Liu 2,3,* Li 4,* Jikai 1 Cheng 2 Chang Nan Ge 5 Hongbo Ren Keqiang Yan Sanyuan Hu 6 Magnus Bjorkholm Yidong Fan Dawei Xu 2,5 Department of Urology, Shandong University Qilu Hospital, Jinan, China Medicine, Division Hematology and Centre for Molecular Karolinska Hospital Solna Institutet, Stockholm, Sweden 3 Microbiology, School 4 Nursing, Urology Central Research Laboratory, Second General Surgery, * These authors contributed equally to this work Correspondence: Xu, email: Fan, Keywords : Promoter mutation, RCC, TERT, Telomerase, UTUC Received January 27, 2014 Accepted March 15, Published 16, 204 Abstract TERT promoter mutations are identified in many malignancies including bladder cancer (BC) upper tract urothelial carcinoma (UTUC). In contrast, no were found renal cell (RCC) as reported a recent study. Because the mutant urine DNA was recently tested marker BC, it is important ascertain whether these truly absent RCCs. Here we determined 109 patients with RCC 14 UTUC. The 9/96 (9.3%) clear (ccRCC) tumors 1/8 (13%) chromophobe tumors. Among ccRCC patients, mutation correlated advanced stages metastasis, higher expression. UTUCs, detected from 3/5 (60%) pelvic 1/9 (11%) ureter cancer. also samples mutation+ Collectively, do occur RCCs associated aggressive disease. more frequent Thus, may come not only but or