Expression of fibrogenic cytokines in desmoplastic malignant melanoma
作者： Kubo , Kikuchi , Nashiro , Kakinuma , Hayashi
DOI: 10.1046/J.1365-2133.1998.02354.X
关键词:
摘要: Desmoplastic malignant melanoma (DMM) consists of amelanotic spindle-shaped cells and is accompanied by desmoplasia with fibrous stromata. It has a strong tendency for local infiltrative growth recurrence propensity neurotropism. not yet known which cytokine responsible the in DMM. In present study, we investigated roles several fibrogenic cytokines receptors DMM: basic fibroblast factor (bFGF), connective tissue (CTGF), transforming factor-beta, platelet-derived (PDGF) PDGF receptors. Immunostaining situ hybridization were conducted four cases DMM (AMM) as negative controls desmoplasia. PDGF-beta receptor, bFGF CTGF intensely expressed specimens comparison AMM specimens. The reaction PDGF-B ligand to addition expression bFGF, may contribute
sci-hub.se 参考文章(24)
Harry N. Antoniades, Cha K. Chung, Expression of c-sis/platelet-derived growth factor B, insulin-like growth factor I, and transforming growth factor alpha messenger RNAs and their respective receptor messenger RNAs in primary human gastric carcinomas: in vivo studies with in situ hybridization and immunocytochemistry. Cancer Research. ,vol. 52, pp. 3453- 3459 ,(1992)
R. Montesano, J. D. Vassalli, A. Baird, R. Guillemin, L. Orci, Basic fibroblast growth factor induces angiogenesis in vitro. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 7297- 7301 ,(1986) , 10.1073/PNAS.83.19.7297
Atsuyuki Igarashi, Kiyoko Nashiro, Kanako Kikuchi, Shinichi Sato, Hironobu Ihn, Gary R. Grotendorst, Kazuhiko Takehara, Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic Sclerosis Journal of Investigative Dermatology. ,vol. 105, pp. 280- 284 ,(1995) , 10.1111/1523-1747.EP12318465
C. Behl, U. Bogdahn, J. Winkler, R. Apfel, W. Brysch, K.H. Schlingensiepen, Autoinduction of Platelet Derived Growth Factor (PDGF) A-Chain mRNA Expression in a Human Malignant Melanoma Cell Line and Growth Inhibitory Effects of PDGF-A-Chain mRNA-Specific Antisense Molecules Biochemical and Biophysical Research Communications. ,vol. 193, pp. 744- 751 ,(1993) , 10.1006/BBRC.1993.1688
N. Hayashi, K. Takehara, Y. Soma, Differential chemotactic responses mediated by platelet-derived growth factor alpha- and beta-receptors. Archives of Biochemistry and Biophysics. ,vol. 322, pp. 423- 428 ,(1995) , 10.1006/ABBI.1995.1484
R.L. BARNHILL, M. XIAO, D. GRAVES, H.N. ANTONIADES, Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo British Journal of Dermatology. ,vol. 135, pp. 898- 904 ,(1996) , 10.1046/J.1365-2133.1996.D01-1092.X
S. Tanizawa, M. Ueda, C. M. van der Loos, A. C. van der Wal, A. E. Becker, Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study. Heart. ,vol. 75, pp. 549- 556 ,(1996) , 10.1136/HRT.75.6.549
Suad AL-ALousi, John A. Carlson, Karen Blessing, Martin Cook, Themis Karaoli, Raymond L. Bamhill, Expression of basic fibroblast growth factor in desmoplastic melanoma Journal of Cutaneous Pathology. ,vol. 23, pp. 118- 125 ,(1996) , 10.1111/J.1600-0560.1996.TB01284.X
H. N. Antoniades, T. Galanopoulos, J. Neville-Golden, C. J. O'Hara, Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 3942- 3946 ,(1992) , 10.1073/PNAS.89.9.3942
C-H Heldin, A Hammacher, M Nistér, B Westermark, Structural and functional aspects of platelet-derived growth factor. British Journal of Cancer. ,vol. 57, pp. 591- 593 ,(1988) , 10.1038/BJC.1988.134