Outbreaks of hand, foot, and mouth disease by enterovirus 71: high incidence of complication disorders of central nervous system.

摘要: In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders the central nervous system, one in 1973 other 1978. The isolated virus both was enterovirus 71. Central system were present 24% patients 8% These localised encephalitis cerebellar signs as main feature, aseptic meningitis, polio-like paresis. 71 strong dermatotropic well neurotropic tendencies. However cross-neutralisation tests, no difference antigenicity from prototype, BrCr strain, recognised.