The Biliary Excretion and Enterohepatic Circulation of Drugs and Other Organic Compounds
作者： Robert L. Smith
DOI: 10.1007/978-3-0348-4021-7_5
关键词:
摘要: The biological activity of drugs in the body is usually terminated by a combination processes metabolism and excretion. metabolic changes undergone vivo are general directed to formation metabolites which have physico-chemical properties favourable for their rapid elimination from body. final products metabolism, or de-toxication products, highly polar these behave as efficient substrates transfer mechanisms functioning excretory organs. Furthermore, polarity tends confine them extra-cellular fluid, another factor conducive elimination.
springer.com
sci-hub.se 参考文章(143)
Leon Hellman, H. Leon Bradlow, Jerome Adesman, David K. Fukushima, J. Lawrence Kulp, T. F. Gallagher, THE FATE OF HYDROCORTISONE-4-C14 IN MAN 1 Journal of Clinical Investigation. ,vol. 33, pp. 1106- 1115 ,(1954) , 10.1172/JCI102984
A. J. RYAN, S. E. WRIGHT, Biliary excretion of some azo dyes related to tartrazine. Nature. ,vol. 195, pp. 1009- 1009 ,(1962) , 10.1038/1951009A0
Gray H. Twombly, Erwin F. Schoenewaldt, Tissue localization and excretion routes of radioactive diethylstilbestrol Cancer. ,vol. 4, pp. 296- 302 ,(1951) , 10.1002/1097-0142(195103)4:2<296::AID-CNCR2820040214>3.0.CO;2-I
A. ALBERT, JOSEPH EDWARD RALL, F.RAYMOND KEATING, MARSCHELLE H. POWER, MARVIN M. D. WILLIAMS, The behavior of labeled thyroglobulin and labeled thyroxine in patients with myxedema. The Journal of Clinical Endocrinology and Metabolism. ,vol. 9, pp. 1392- 1405 ,(1949) , 10.1210/JCEM-9-12-1392
L. BRADSHAW, D. B. CLAYSON, Metabolism of two aromatic amines in the dog. Nature. ,vol. 176, pp. 974- 975 ,(1955) , 10.1038/176974A0
F. N. BRIGGS, ALVIN TAUROG, I. L. CHAIKOFF, The enterohepatic circulation of thyroxine in the rat. Endocrinology. ,vol. 52, pp. 559- 567 ,(1953) , 10.1210/ENDO-52-5-559
Norman B. Javitt, Henry O. Wheeler, Katharine J. Baker, Oswaldo L. Ramos, Stanley E. Bradley, THE INTRAHEPATIC CONJUGATION OF SULFOBROMOPH-THALEIN AND GLUTATHIONE IN THE DOG * Journal of Clinical Investigation. ,vol. 39, pp. 1570- 1577 ,(1960) , 10.1172/JCI104178
K. Zehnder, F. Kalberer, W. Kreis, J. Rutschmann, The metabolism of thioridazine (mellaril®) and one of its pyrrolidine analogues in the rat Biochemical Pharmacology. ,vol. 11, pp. 535- 550 ,(1962) , 10.1016/0006-2952(62)90114-4
K. Junkmann, Perorale Cholecystographie mit Biliselectan Journal of Molecular Medicine. ,vol. 20, pp. 125- 128 ,(1941) , 10.1007/BF01879222
Elizabeth K. Weisburger, John H. Weisburger, Harold P. Morris, Studies on the metabolism of 2-acetylaminofluorene-9-C14. Archives of Biochemistry and Biophysics. ,vol. 43, pp. 474- 484 ,(1953) , 10.1016/0003-9861(53)90142-8