Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.

摘要: Abstract In the inbred C57BL/6N mouse, aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons increases rapidly in neonatal period; this response to these pharmacological, exogenous compounds does not appear DBA/2N, NZW/BLN, or NZB/BLN strains. The development of constitutive activity period is same all four Small differences pH optima, substrate affinities, relative thermolability, benzo[a]pyrene metabolism, which might have affected enzyme assay, do account for large genetic difference hydrocarbons. aromatic inherited as a simple autosomal dominant trait, designated ah locus. individual mouse that genetically responsive hydrocarbons, induced an all-or-none phenomenon tissues regularly contain hydrocarbon-inducible enzyme. magnitude 4- 5-fold liver, and ranges from 5- more than 80-fold kidney, bowel, lung, skin. formation spectrally distinct carbon monoxide-binding cytochrome liver microsomes associated with seen mice are nonresponsive Phenobarbital induces hepatic oxygenase similar levels (i.e. about 2-fold)