Prevention of degenerative disease: A controlled study of anticoagulant prophylaxis

作者: J.R. Whittier , C. Korenyi , D.F. Klein , W. Foley

DOI: 10.1016/0021-9681(61)90153-9

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摘要: Abstract A placebo-controlled trial of the prophylactic value anticoagulant (Dicumarol) medication was conducted on a population 162 subjects selected from 540 male patients aged 60 and over admitted to state hospital for first time, distributed in random manner into treated, control, observation groups. For selected, under rigorous clinical it observed that: 1. Mortality receiving Dicumarol 11 per cent compared with 28 placebo. This difference statistically significant at 5 level confidence. 2. Mean survival time study who died more than twice as long Dicumarol. 3. Major hemorrhage occurred 20 In 9 site which bleeding appeared “aggravated by medication.” without other causes competent produce believed “due

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