Biomonitoring exposures to carcinogens
作者： Sofia Pavanello , Marcello Lotti
DOI: 10.1016/B978-0-12-404630-6.00047-6
关键词:
摘要: A wide array of analytical tools exists to assess biological parameters, referred as biomarkers, that in clinical medicine are used indicators normal or pathological processes, and pharmacological responses. In environmental occupational health the term biomarker is differently, indicating signaling events systems samples aimed at preventing adverse effects exposures. procedure known human biomonitoring measures size exposures chemicals, their biochemical effects, individual susceptibility. This chapter summarizes biomarkers currently for carcinogen highlights value limitations, restricting examples those chemicals classified groups 1 2A by International Agency Research on Cancer. Several tests monitor individuals exposed carcinogens have been introduced, but preventive relevance uncertain. new era may result from application novel high-throughput techniques.
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sci-hub.se 参考文章(207)
Lyaskivska O, Bazyka D, Ilyenko I, Analysis of relative telomere length and apoptosis in humans exposed to ionising radiation. Experimental Oncology. ,vol. 33, pp. 235- ,(2011)
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework* Clinical Pharmacology & Therapeutics. ,vol. 69, pp. 89- 95 ,(2001) , 10.1067/MCP.2001.113989
Igor P. Pogribny, Ivan Rusyn, Environmental Toxicants, Epigenetics, and Cancer Advances in Experimental Medicine and Biology. ,vol. 754, pp. 215- 232 ,(2013) , 10.1007/978-1-4419-9967-2_11
Raluca A. Mateuca, Ilse Decordier, Micheline Kirsch-Volders, Cytogenetic Methods in Human Biomonitoring: Principles and Uses Methods in Molecular Biology. ,vol. 817, pp. 305- 334 ,(2012) , 10.1007/978-1-61779-421-6_15
John S. Wishnok, Steven R. Tannenbaum, Rashmi Sinha, La Creis R. Kidd, W. G. Stillwell, Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity. Cancer Research. ,vol. 57, pp. 3457- 3464 ,(1997)
Maria Wojewódzka, Marcin Kruszewski, Teresa Iwaneñko, Andrew R. Collins, Irena Szumiel, Application of the comet assay for monitoring DNA damage in workers exposed to chronic low-dose irradiation: I. Strand breakage Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 416, pp. 21- 35 ,(1998) , 10.1016/S1383-5718(98)00073-4
J Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski, Vesna Slavkovich, Diane Levy, Pam Factor-Litvak, Joseph H Graziano, Mary V Gamble, Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults The American Journal of Clinical Nutrition. ,vol. 86, pp. 1179- 1186 ,(2007) , 10.1093/AJCN/86.4.1179
F F Kadlubar, P Vineis, N E Caporaso, C Malaveille, S Tannenbaum, H Bartsch, P Shields, P Skipper, M T Landi, I Bernucci, C Zocchetti, Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 5, pp. 693- 698 ,(1996)
R. D. Johnson, Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells The EMBO Journal. ,vol. 19, pp. 3398- 3407 ,(2000) , 10.1093/EMBOJ/19.13.3398
Ivan Kalina, Peter Brezáni, Dagmar Gajdošová, Blanka Binková, Ján Šalagovič, Viera Habalová, Gabriela Mračková, Lubomı́r Dobiáš, Radim J. Šrám, Cytogenetic monitoring in coke oven workers Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 417, pp. 9- 17 ,(1998) , 10.1016/S1383-5718(98)00089-8