Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
作者： Franz Bauernfeind , Eva Bartok , Anna Rieger , Luigi Franchi , Gabriel Núñez
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摘要: … that ROS activate proinflammatory transcription factors (19, 20) and that ROS production … On the basis of these findings, we hypothesized that ROS inhibition does not directly affect …
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J T Hancock, O T Jones, The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. Biochemical Journal. ,vol. 242, pp. 103- 107 ,(1987) , 10.1042/BJ2420103
Juana M Sanz, Francesco Di Virgilio, None, Kinetics and Mechanism of ATP-Dependent IL-1β Release from Microglial Cells Journal of Immunology. ,vol. 164, pp. 4893- 4898 ,(2000) , 10.4049/JIMMUNOL.164.9.4893
Felix Meissner, Reinhard A. Seger, Despina Moshous, Alain Fischer, Janine Reichenbach, Arturo Zychlinsky, Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease Blood. ,vol. 116, pp. 1570- 1573 ,(2010) , 10.1182/BLOOD-2010-01-264218
Yasunari Takada, Asok Mukhopadhyay, Gopal C. Kundu, Ganapati H. Mahabeleshwar, Sujay Singh, Bharat B. Aggarwal, Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65: EVIDENCE FOR THE INVOLVEMENT OF IκBα KINASE AND Syk PROTEIN-TYROSINE KINASE Journal of Biological Chemistry. ,vol. 278, pp. 24233- 24241 ,(2003) , 10.1074/JBC.M212389200
Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Luigi Franchi, Joel Whitfield, Winfried Barchet, Marco Colonna, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P. Grant, Shizuo Akira, Gabriel Núñez, Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 Nature. ,vol. 440, pp. 233- 236 ,(2006) , 10.1038/NATURE04517
Rongbin Zhou, Amir S. Yazdi, Philippe Menu, Jürg Tschopp, A role for mitochondria in NLRP3 inflammasome activation Nature. ,vol. 469, pp. 221- 225 ,(2011) , 10.1038/NATURE09663
C. Dostert, V. Petrilli, R. Van Bruggen, C. Steele, B. T. Mossman, J. Tschopp, Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. ,vol. 320, pp. 674- 677 ,(2008) , 10.1126/SCIENCE.1156995
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel, Jürg Tschopp, Gout-associated uric acid crystals activate the NALP3 inflammasome Nature. ,vol. 440, pp. 237- 241 ,(2006) , 10.1038/NATURE04516
Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu, Emad S. Alnemri, AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA Nature. ,vol. 458, pp. 509- 513 ,(2009) , 10.1038/NATURE07710
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis, Franz Bauernfeind, Gabor Horvath, Daniel. R. Caffrey, Eicke Latz, Katherine A. Fitzgerald, AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC Nature. ,vol. 458, pp. 514- 518 ,(2009) , 10.1038/NATURE07725