Time and space profiling of NMDA receptor co-agonist functions.

摘要: The N-Methyl D-Aspartic acid (NMDA) receptors (NMDAR) are key tetrameric ionotropic glutamate that transduce glutamatergic signals throughout the central nervous system (CNS) and spinal cord. Although NMDARs diverse in their subunit composition, subcellular localization, biophysical pharmacological properties, activation always requires binding of a co-agonist has long been thought to be glycine. However, intense research over last decade challenged this classical model by showing another amino acid, d-serine, is preferential for subset synaptic many areas adult brain. Nowadays, totally new picture synapses at work emerging where both glycine d-serine involved complex interplay regulate NMDAR functions CNS following time space constraints. purpose review was highlight particular role each modulating NMDAR-dependent activities healthy diseased brains. We have herein integrated our most advanced knowledge how may orchestrate synapse dynamics drive neuronal network activity time- synapse-specific manner changes availability these acids contribute cognitive impairments such as those associated with aging, epilepsy, schizophrenia. subtype physiological linked brain disorders. Their require or After years controversy on identity serves right co-agonist, we just entering era consensus teaming up function different subsets NMDA during windows development.