Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

摘要: Alterations in the molecular mechanisms of cell death are a common feature cancer. These alterations enable malignant cells to survive intrinsic signalling leading accumulation genetic aberrations and helping them cope with adverse conditions. Regulated has historically been exclusively associated classical apoptosis; however, increasing evidence indicates that several alternative orchestrate multiple pathways, such as ferroptosis, entosis, necroptosis immunogenic death, each distinct underlying mechanisms. Although pharmacological targeting pathways subject intensive efforts recent decades dominant focus on apoptosis, identification these novel opened additional venues for intervention cancer immune system. In this mini-review, we cover some progress major recently emerged modalities, emphasizing their potential clinical therapeutic implications. We also discuss interplay between response, highlighting combination traditional anticancer therapy immunocheckpoint blockade. While attempting stimulate discussion draw attention possible impact more achieved translating strategies manipulation apoptotic into clinic, focusing attempts target anti-apoptotic protein BCL2 tumour suppressor p53.