Trypanosuppresive effects of ellagic acid and amelioration of the trypanosome-associated pathological features coupled with inhibitory effects on trypanosomal sialidase in vitro and in silico.

摘要: Abstract Background The search for novel antitrypanosomal agents had previously led to the isolation of ellagic acid as a bioactive compound using in vitro studies. However, it is not known whether this will elicit activity vivo condition which usually next step drug discovery process. Purpose Herein, we investigated against bloodstream form Trypanosoma congolense and its ameliorative effects on trypanosome-induced anemia organ damage well inhibitory trypanosomal sialidase. Methods Rats were infected with T. treated 100 200 mg/kg body weight (BW) fourteen days. levels parasitemia, packed cell volume biochemical parameters measured. Subsequently, sialidase was partially purified DEAE cellulose column mode inhibition determined. Molecular docking study also conducted determine interaction catalytic domain rangeli Results At dose (BW), demonstrated significant (P  Conclusion We concluded that possesses trypanosuppressive could ameliorate pathological alterations.