The role of Dsb proteins of Gram-negative bacteria in the process of pathogenesis.

摘要: Tertiary and quaternary structures of extracytoplasmic proteins containing more than one cysteine residue often require introduction disulfide bonds. This process takes place in an oxidative environment, such as the periplasm Gram-negative bacteria, is catalyzed by Dsb (disulfide bond formation) proteins. Mutations dsb genes influence conformation stability many Thus, pathogens become partially or fully attenuated due to improper folding that act virulence factors. review summarizes current knowledge on their effect pathogenicity bacteria. The potential application biotechnology also discussed.