HPV and Cancer: Epidemiology and Mechanism of Carcinogenesis of the Virus HPV
作者： Silvia de Sanjosé , Laia Alemany
DOI: 10.1007/978-3-319-18257-5_16
关键词:
摘要: Human papillomavirus is one of the most common viral agents infecting skin and mucoses in humans. It now well established that persistent HPV infection with some specific types, so-called high-risk leads to a deregulation gene expression altered cell functions including proliferation, poor DNA repair, accumulation genetic changes. All these changes are linked anogenital cancers cervix, vagina, vulva, anal canal, penis head neck cancers, particularly oropharyngeal. The etiological contribution differs each location reflecting different natural history tropism. contributes over 530,000 new cervical cancer cases 80,000 other related sites every year worldwide. Geographical social differences incidence mortality prominent for as its burden highly screening treatment facilities. Prevention strategies moving towards incorporating testing practices vaccination primary prevention. vaccines represent avenue prevention potential contribute reduction wide range HPV-related diseases.
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