Breast Cancer after Multiple Chest Fluoroscopies: Second Follow-up of Massachusetts Women with Tuberculosis

摘要: Abstract A second follow-up was conducted of 1742 women with tuberculosis who were treated in one two sanatoria Massachusetts between 1930 and 1956. One hospital only children under the age 17. Patient extended from 1975 through 1980, an additional 18 breast cancers identified records, death certificates, responses to a mailed questionnaire. Vital status established for 97% subjects. Among 1044 examined average 101 times X-ray fluoroscopies during lung collapse therapy, 55 observed contrast 35.8 expected, based on incidence rates general population. No excess found 698 by other means (19 versus 22.8 expected). Excess cancer risk did not appear until 15 years after initial exposure present at end 50 observation. Risk appeared decrease increasing exposure. Estimates radiation dose individuals (mean = 96 rad) most current information numbers fluoroscopies, reconstruction conditions, absorbed calculations. The relation consistent linearity up 400 rads (4 Gy). For 10-year survivors, absolute 5.5/1 million woman-year-rad, relative per rad 0.73%, 100 1.7. These data indicate that woman9s lifetime is influenced events occurring early reproductive life, low-dose fractionated exposures are as effective single same total inducing cancer, radiogenic persists many years, perhaps life.