Proton pump inhibitor use is associated with increased rates of post-TIPS hepatic encephalopathy: Replication in an independent patient cohort

摘要: Abstract Purpose Proton pump inhibitor (PPI) use is a potential risk factor for hepatic encephalopathy (HE), but few studies have examined the effect on post-TIPS HE. The purpose of this study was to determine whether PPIs are associated with increased rates HE in an independent patient cohort. Materials and methods This single-institution retrospective analyzed 86 patients (54 male, mean age 58.2) following TIPS from 1/1/2017 12/31/2019. Dates PPI usage episodes new or worsening were recorded. Poisson regression generalized estimating equations used test association between dose dependence. Post-TIPS also using Andersen-Gill survival model recurrent events. Results There 1.88 per person-year among 35 uninterrupted therapy, 1.95 0.94 off intermittent 0.47 16 never PPIs. significantly both univariable (incidence rate ratio (IRR) = 2.62; CI = 1.41–4.84; p = 0.002) multivariable (IRR = 2.31; CI = 1.37–3.89; regression. Analysis only those showed higher doses (IRR = 1.17 10 mg omeprazole equivalent; CI = 1.04–1.33; p = 0.011). Recurrent events analysis supported (hazard (HR) = 2.17; CI = 1.19–3.95; p = 0.011) (HR = 1.87; CI = 1.12–3.13; p = 0.017) analysis. Conclusion In cohort