Staging B-Cell Development and the Role of Ig Gene Rearrangement in B Lineage Progression
作者： Richard R. Hardy , Susan Shinton , Robert Wasserman , Yue-Sheng Li
DOI: 10.1007/978-1-4757-2778-4_14
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摘要: As B lymphocytes are generated from hematopoietic stem cells, they pass through several intermediate stages that characterized by distinctive molecular and functional features. The earliest stage is distinguished accessibility of the immunoglobulin (Ig) heavy chain locus, indicating chromatin changes preparatory to rearrangement. Upon activation recombinase complex, first a diversity (D) region segment rearranges one four joining (J) segments (usually on both chromosomes), then 50–100 variable (V) genes D-J segment. If this attempt fails generate productive (inframe) protein coding sequence, second V DJ rearrangement can occur other chromosome. Expression in cytoplasm marks classical pre-B-cell signals cell progress next B-cell differentiation—clonal expansion followed light J at locus results expression complete IgM molecule, which rapidly transported surface immature B-cell. Further differentiation (and possibly selection) finally generates IgM+IgD+ mature
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