Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells.
作者： K. Rezonja , P. Lorenzon , T. Mars
DOI: 10.1016/J.NEULET.2013.06.014
关键词:
摘要: Neuromuscular junction development is the key process required for successful neuromuscular transmission and functional innervation of skeletal muscle fibres. Various substances can influence these processes, some which are in common use clinical practice. In present study, effects potentially new therapeutic agent agrin were followed, along with widely used glucocorticoid dexamethasone. The vitro experimental model was constitutive interleukin 6 (IL-6) secretion human cells. Additionally, selective relaxant binding sugammadex its possible interaction dexamethasone followed. Dexamethasone impaired while had opposing effects. Furthermore, based on interference IL-6 secretion, we show potential (chemical) interactions between sugammadex. physiological this should be taken into consideration under conditions where two drugs might applied simultaneously.
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