ABDOMINAL OBESITY AND ITS METABOLIC COMPLICATIONS : IMPLICATIONS FOR THE RISK OF ISCHAEMIC HEART DISEASE

摘要: Although the health hazards of obesity are well established, obese individuals not all at equal risk developing a disease, which reflects heterogeneity this condition. The regional distribution body fat is now recognized as very important component obesity-related hazards. Epidemiological studies have shown that abdominal obesity, is, preponderance in area, better predictor both cardiovascular disease and type 2 diabetes than per se. It generally accepted located within cavity, visceral fat, best correlate most highly atherogenic metabolic complications seen with obesity. These include, among others, insulin resistance hyperinsulinaemia, hypertriglyceridaemia, reduced plasma high-density lipoprotein (HDL) cholesterol concentrations an increased number small, dense low-density (LDL) particles. This review summarizes evidence these may account to large extent for associated abdominal/visceral Abdominal be prevalent denominator dyslipidaemic hyperinsulinaemic/insulin-resistant states affluent, sedentary societies. Targeting high-risk trait primary prevention therefore crucial if we truly impact on incidence disease.