Selenium Inhibition of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis

摘要: The inhibitory effect of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Sprague-Dawley rats is presented. A 4-ppm supplement to the drinking water was provided concurrently with DMH treatment and continued until death or sacrifice. Rats were administered 10 weekly injections mg per kg body weight. Thirtyone weeks following tenth injection, all surviving animals sacrificed. At sacrifice, tumor incidence DMH-only controls 8 28 (29%). Selenium supplementation significantly (p less than 0.01) reduced 1 37 (3%). cumulative for found dead sacrificed also 0.05) from 11 40 3 DMH-selenium-supplemented rats. total number tumors 13 3, average rat 1.2 1.0 by supplemental selenium. majority (greater 65%) located distal colon. serum glutamic oxaloacetic transaminase, alkaline phosphatase, complete blood count normal equivalent only, DMH-selenium, untreated control groups this study. glutathione S-transferase activity liver cytosol preparations increased 39.6 +/- 7.3 (S.D.) microM product/min/mg (DMH only) 67.6 5.8 only 54.3 10.6 selenium-DMH-treated Protection may part be attributed enhanced detoxification carcinogenic electrophiles.