Imidazopyridines and imidazopyrazines as lsd1 inhibitors

作者: Liangxing Wu , Colin Zhang , Liang Lu , Neil Lajkiewicz , Leah C. Konkol

DOI:

关键词:

摘要: The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

参考文章(388)
Pingyu Ding, Somasekhar Bhamidipati, Todd Kinsella, Jeffrey Clough, Donald Payan, Rajinder Singh, Marina Gelman, GDF-8 inhibitors ,(2013)
Darren Mark Legrand, Thomas Anthony Hunt, James Dale, Ian Bruce, Bicyclic heteroaryl compounds and their use as kinase inhibitors ,(2008)
Julio Cesar Castro Palomino Laria, Alberto Ortega Munoz, Jonathan Alleman Baker, Nathalie Guibourt, Inhibitors for antiviral use ,(2011)
Carlos Buesa Arjol, Tamara Maes, Cyclopropylamine derivatives useful as lsd1 inhibitors ,(2011)
Subramaniam Ananthan, Ashish K. Pathak, Dong Hong Chung, Bill Severson, Clinton Boykin Maddox, Joseph A. Maddry, Colleen B. Jonsson, Lynn Rasmussen, Ellie Lucile White, Anti-viral treatment and assay to screenfor anti-viral agent ,(2011)
Katsuhiro Kawakami, Tetsunori Fujisawa, Kazuo Kanai, Chikanori Morita, Takashi Suzuki, Heterocyclic compounds having antifungal activity ,(2005)
Dong-Chan Oh, So Hee Kwon, Jongheon Shin, Hak Cheol Kwon, Seong-Hwan Kim, Compound, preparing method thereof, and use thereof as inhibitors of histone demethylase ,(2014)
Michele Potashman, Aaron Siegmund, Markian Stec, Stephanie Springer, Ning Xi, Deborah Choquette, Alessandro Boezio, Steven Bellon, Jean-Christophe Harmange, Randall Hungate, Longbin Liu, Tae-Seong Kim, Christiane Bode, Satoko Hirai, Shon Booker, David Bauer, Julia Lohman, Richard Lewis, Mark Norman, Kevin Yang, Derin D'amico, Brian Albrecht, Fused heterocyclic derivatives useful as inhibitors of the hepatocyte growth factor receptor ,(2007)
Andrea Haegebarth, Stuart Ince, Roland Neuhaus, Oliver Politz, William Scott, Ulf Bömer, Substituted imidazo[1,2-a]pyrimidines and —pyridines ,(2011)
He Zhao, Jun Yuan, Shaojing Hu, Hongbin Li, Qin Guo, Jianmin Mao, Darren Whitehouse, Jack Hammer, David Wustrow, Wallace Fringle, George Maynard, Subtituted heteroaryl cb1 antagonists ,(2006)