Nephrotoxic Potential of cis-Diamminedichloroplatinum and Four Analogs in Male Fischer 344 Rats

摘要: Cis-diamminedichloroplatinum [cis-DDP; NSC-119875] and four analogs (NSC-241240, NSC-271674, NSC-263158, NSC-268252) were evaluated for their acute nephrotoxic potential in male F344 rats following iv administration. Indices of nephrotoxicity included blood urea nitrogen, serum creatinine, kidney weights, microscopic examination. Results indicated that renal function, organ histology are important criteria assessing the cis-DDP analogs, although alterations these parameters may have been influenced by severe body weight loss. appeared to be most compound studied, NSC-241240 demonstrated minimal damage. Ranking compounds order (most least) was cis-DDP, NSC-268252, NSC-241240.