Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells
作者： Fabiana Fernandez , Michael Wacker , Michael Wetter , Michael Kowarik
DOI:
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摘要: The present invention is directed to a bioconjugate vaccine, such as an Ol-bioconjugate comprising: protein carrier comprising containing at least one consensus sequence, D/E - X N Z S/T, wherein and may be any natural amino acid except proline; antigenic polysaccharide from pathogenic bacterium, linked the carrier; and, optionally, adjuvant. In another aspect, method of producing O1-bioconjugate in bioreactor number steps.
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