A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet.

摘要: 14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees, acts as bioactive phytonutrient that can treat many diseases. To investigate the protective effects of deAND on reducing fatty liver disease, male mice were fed high-fat and high-cholesterol (HFHC) diet without or with 0.05% 0.1% supplementation. Cholesterol accumulation, antioxidant, anti-inflammatory activities injury evaluated after treatment. The results show treatment for seven weeks reduced plasma alanine aminotransferase activity lowered hepatic cholesterol tumor nuclear factor-α, histological lesions. HFHC diet-induced apoptosis by lowering caspase 3/pro-caspase 3 ratio. After 11 treatment, increased NOD-like receptor protein (NLRP3), capase-1, interleukin-1β levels suppressed In addition, factor erythroid 2-related 2 (Nrf2) mRNA expression, heme oxygenase-1 glutathione peroxidase reductase diet. However, those antioxidant enzymes proteins also upregulated Furthermore, tended to lower lipid peroxides. Finally, reversed depletion glutamate level induced These indicate may ameliorate steatohepatitis increasing activities.