Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.

摘要: The rostral ventrolateral medulla is the primary site of action for clonidine, a centrally acting antihypertensive. In medulla, clonidine binds not only to alpha-2 adrenergic receptors but also specific imidazole sites. order determine whether putative receptor mediates hypotensive series compounds was tested 1) in vitro binding affinity at and sites 2) vivo ability lower arterial pressure heart rate when microinjected directly into medulla. Hypotensive potency correlated with (r = 0.84), -0.05). bradycardia elicited by this 0.89), 0.10). Furthermore, idazoxan selectively reversed fall whereas SKF-86466, an antagonist which imidazole, failed attenuate clonidine's action. An appears mediate central actions related imidazoles may participate regulation rate.