epigallocatechin gallate prodrugs preparation method thereof and composition for mitochondrial biosis
作者： You Hoon Choung , Mi Kyoung Kim , Shin Seonhye
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摘要: The present invention relates to an epigallocatechin gallate prodrug, a method for manufacturing the same, and composition promoting mitochondrial biosynthesis comprising same. A compound represented by chemical formula (1) according increases activity of PGC-1α, AMPK, SIRT1, known as regulators, amount DNA, NAD+/NADH ratio, level cytochrome c, synthesis ATP, oxygen consumption, thereby confirming effect increasing biosynthesis. In addition, it is confirmed that has having high absorption rate slow metabolism in vivo compared existing gallate, being useful purpose preventing or treating diseases related dysfunction.
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