Non-Coding RNA in Pancreas and β-Cell Development

摘要: In this review, we provide an overview of the current knowledge on role different classes non-coding RNAs for islet and β-cell development, maturation function. MicroRNAs (miRNAs), a prominent class small RNAs, have been investigated more than two decades patterns roles miRNAs in pancreatic fetal function are now emerging. Specific dynamically regulated throughout period pancreas during differentiation as well perinatal period, where burst replication takes place. The long (lncRNA) β-cells is less miRNAs, but increasing rapidly. advent ultra-deep RNA sequencing has enabled identification highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their cells currently only characterized few these lncRNAs, often associated with super-enhancers regulate neighboring gene activity. Moreover, ncRNAs present imprinted regions involved development Altogether, observations support significant important actions