Wnt in Hematopoietic and Leukemic Stem Cells

摘要: When first discovered, it was clear that Wnts and their downstream targets played a pivotal role in the evolution of cancer mice. However, recent research has underscored importance Wnt pathway essential regenerative repair processes, particularly maintenance self-renewing, blood-forming stem cells. Seminal studies involving multiplicity human cancers revealed epigenetic genetic changes activated pathway, primarily through deregulation destruction complex, rendering vital potential therapeutic target cancer. is prominent leukemia, which provided an important paradigm for dissecting molecular mechanisms involved cell type context-specific manner. Perhaps most importantly, discovery leukemia cells impetus investigating fueling characteristically unbridled self-renewal capacity. In this review, we examine contribution to normal hematopoietic (HSC) versus leukemic (LSC) propagation order establish whether index likely exist will warrant development inhibitor clinical trials