Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling.

作者: Qi-wei Jiang , Denis Kaili , Jonaye Freeman , Chong-yang Lei , Bing-chuan Geng

DOI: 10.1038/S41401-019-0223-Y

关键词:

摘要: … Treatment with an antioxidant N-acetyl cysteine (NAC, 100 μM) significantly decreased ROS … reduced in both diabetic mouse and human CEC, while NAC treatment mitigated these …

参考文章(53)
Yoshio Goto, Ken-ichi Suzuki, Toshio Ono, Masayoshi Sasaki, Takayoshi Toyota, Development of Diabetes in the Non-Obese NIDDM Rat (GK Rat) Prediabetes. ,vol. 246, pp. 29- 31 ,(1988) , 10.1007/978-1-4684-5616-5_4
Fu-Shin X. Yu, Yuan Wang, Xian-jin Yi, Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 4093- 4100 ,(2000)
Hamdy Abdelkader, Dipika V Patel, Charles NJ McGhee, Raid G Alany, New therapeutic approaches in the treatment of diabetic keratopathy: a review Clinical and Experimental Ophthalmology. ,vol. 39, pp. 259- 270 ,(2011) , 10.1111/J.1442-9071.2010.02435.X
Maria João Quadrado, Monika Popper, António Miguel Morgado, Joaquim Neto Murta, Jaap A Van Best, Diabetes and corneal cell densities in humans by in vivo confocal microscopy. Cornea. ,vol. 25, pp. 761- 768 ,(2006) , 10.1097/01.ICO.0000224635.49439.D1
Long Shi, Hongmei Chen, Xiaoming Yu, Xinyi Wu, Advanced glycation end products delay corneal epithelial wound healing through reactive oxygen species generation. Molecular and Cellular Biochemistry. ,vol. 383, pp. 253- 259 ,(2013) , 10.1007/S11010-013-1773-9
Judith Friend, Yasuo Ishíi, Richard A. Thoft, Corneal Epithelial Changes in Diabetic Rats Ophthalmic Research. ,vol. 14, pp. 269- 278 ,(1982) , 10.1159/000265202
Ian S. Zagon, Use of Topical Insulin to Normalize Corneal Epithelial Healing in Diabetes Mellitus Archives of Ophthalmology. ,vol. 125, pp. 1082- 1088 ,(2007) , 10.1001/ARCHOPHT.125.8.1082
Richard O. Schultz, Mark A. Peters, Kathleen Sobocinski, Kamal Nassif, Karen J. Schultz, Diabetic keratopathy as a manifestation of peripheral neuropathy American Journal of Ophthalmology. ,vol. 96, pp. 368- 371 ,(1983) , 10.1016/S0002-9394(14)77829-8
Dimitri T Azar, Sandra J Spurr-Michaud, Ann S Tisdale, Ilene K Gipson, Altered Epithelial-Basement Membrane Interactions in Diabetic Corneas Archives of Ophthalmology. ,vol. 110, pp. 537- 540 ,(1992) , 10.1001/ARCHOPHT.1992.01080160115045