Aging Genes: The Sirtuin Story Unravels

摘要: In 1998, MIT professor Leonard Guarente and his lab began publishing a series of influential papers that linked set genes to calorie restriction, which had been known for years stretch life span in animals, suggesting the possibility drugs could extend human span. But other scientists failed find what they were reporting their experiments. The result is mass confusion over who9s right wrong, high-stakes effort protect reputations, research money, one premier theories biology aging. It9s also story science gone sour: Several principals have dug heels, declined communicate, bitterly derided another. Tensions reached crescendo September, when former member Matt Kaeberlein colleagues published most damning yet, finding no effects from key aging gene worms flies.