Morphological characterization of polyanhydride biodegradable implant gliadel during in vitro and in vivo erosion using scanning electron microscopy.

摘要: Purpose. The objectives of the current study are to characterize distribution chemotherapeutic agent carmustine (BCNU) in spray dried polyanhydride microspheres and describe morphological changes that occur during vitro vivo erosion implant-GLIADEL®, which consists BCNU distributed copolymer matrix poly(carboxyphenoxy propane:sebacic acid) a 20:80 molar ratio (p(CPP:SA, 20:80)). Methods. Scanning electron microscopy (SEM) was used visualize polymer manufacturing process erosion. Results. This revealed homogeneously within with no phase separation. porosity wafer fabricated from gradually increased During initial period following implantation brains rats, mainly confined surface layer majority remaining intact. eroding front advanced interior layerwise fashion, creating pores connecting channel. Eventually both exterior wafers were eroded same porous structure seen throughout whole wafer. Conclusions. provides first visual observation GLIADEL® release drug substance BCNU. observations this support conclusion is controlled by diffusion matrix.