Pingwei capsules improve gastrointestinal motility in rats with functional dyspepsia

摘要: Abstract OBJECTIVE To investigate the mechanism of Pingwei capsules (PWC) in improving gastrointestinal motility rats with functional dyspepsia (FD). METHODS We established an FD model by stimulating semi-starvation via tail damping, provocation, and forced exercise fatigue. The group was further divided into five groups according to treatment received: normal saline, domperidone, low-dose PWC, mid-dose or high-dose PWC. effect PWC on rat evaluated measuring motility. Changes leptin cholecystokinin (CCK) were detected through enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, immunohistochemistry. RESULTS significantly increased rats. Furthermore, CCK mRNA protein concentrations duodenum antrum, decreased duodenum, hypothalamus, concentration hypothalamus. CONCLUSION improve motor function decreasing serum brain-gut axis, increasing tissue. Our findings help elucidate provide insight pharmacokinetics