Chronic Fatigue and Postinfective Fatigue Syndromes

摘要: Chronic fatigue syndrome and postinfective have been the focus of considerable research interest, including epidemiological studies; investigations microbiological, immunologic, neuroendocrine, metabolic, psychological hypotheses etiology; treatment interventions. The most widely known predecessor to current label chronic is disorder termed ‘‘neurasthenia,’’. state was present from time onset symptoms acute infection stable in character over time, suggesting that genesis intrinsically linked host-pathogen interactions phase. prevalent those with mononucleosis documented be due Epstein-Barr virus (EBV) shown essentially independent psychiatric diagnoses. modern era relation has marked by formulation diagnostic criteria. Centers for Disease Control Prevention then proposed term replace numerous previous eponyms. Studies patients overlapping clinical fibromyalgia demonstrated benefit a combination low-dose tricyclic antidepressant nonsteroidal anti-inflammatory agent, where effects on muscle pain sleep disturbance are notable, arguing similar therapeutic trial whom prominent.