The pathophysiology of "happy" hypoglycemia

作者: Thomas Loeb , Michel Baer , Geraldine Baer , Anna Ozguler

DOI: 10.1186/S12245-021-00348-7

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摘要: Background Hypoglycemia usually includes various neurological symptoms, which are the consequence of neuroglycopenia. When it is severe, associated with altered mental status, even coma. Case presentation We report case a patient severe hypoglycemia, completely asymptomatic, due to increase lactate production in response tissue hypoperfusion following hemorrhagic shock. This illustrates that can substitute glucose as an energy substrate for brain. It also reminder this metabolite, despite its bad reputation maintained by role marker severity critical care patients, has fundamental our metabolism. Conclusions Following example "happy hypoxemia" recently reported literature describing asymptomatic hypoxemia COVID-19 we describe hypoglycemia."

参考文章(14)
R. Rimachi, F. Bruzzi De Carvahlo, C. Orellano-Jimenez, F. Cotton, J. L. Vincent, D. De Backer, Lactate/Pyruvate Ratio as a Marker of Tissue Hypoxia in Circulatory and Septic Shock: Anaesthesia and Intensive Care. ,vol. 40, pp. 427- 432 ,(2012) , 10.1177/0310057X1204000307
Georges C. Elhomsy, Vijay Eranki, Stewart G. Albert, Mark J. Fesler, Stacey M. Parker, Amanda G. Michael, George T. Griffing, “Hyper-Warburgism,” a Cause of Asymptomatic Hypoglycemia with Lactic Acidosis in a Patient with Non-Hodgkin's Lymphoma The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, pp. 4311- 4316 ,(2012) , 10.1210/JC.2012-2327
J.-C. Orban, X. Leverve, C. Ichai, Lactate : le substrat énergétique de demain Réanimation. ,vol. 19, pp. 384- 392 ,(2010) , 10.1016/J.REAURG.2010.05.016
L. Pellerin, P. J. Magistretti, Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 10625- 10629 ,(1994) , 10.1073/PNAS.91.22.10625
M. G. Herrera, G. F. Cahill, O. E. Owen, A. P. Morgan, H. G. Kemp, J. M. Sullivan, Brain Metabolism during Fasting* Journal of Clinical Investigation. ,vol. 46, pp. 1589- 1595 ,(1967) , 10.1172/JCI105650
R. D. Cohen, H. F. Woods, Lactic Acidosis Revisited Diabetes. ,vol. 32, pp. 181- 191 ,(1983) , 10.2337/DIAB.32.2.181
Luc Pellerin, Giovanni Pellegri, Philippe G. Bittar, Yves Charnay, Constantin Bouras, Jean-Luc Martin, Nephi Stella, Pierre J. Magistretti, Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle Developmental Neuroscience. ,vol. 20, pp. 291- 299 ,(1998) , 10.1159/000017324
Guillermo Umpierrez, Mary Korytkowski, Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nature Reviews Endocrinology. ,vol. 12, pp. 222- 232 ,(2016) , 10.1038/NRENDO.2016.15
Iciar Martín-Timón, Mechanisms of hypoglycemia unawareness and implications in diabetic patients. World Journal of Diabetes. ,vol. 6, pp. 912- 926 ,(2015) , 10.4239/WJD.V6.I7.912
Cornelis A J van Beers, J Hans DeVries, Susanne J Kleijer, Mark M Smits, Petronella H Geelhoed-Duijvestijn, Mark H H Kramer, Michaela Diamant, Frank J Snoek, Erik H Serné, Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial The Lancet Diabetes & Endocrinology. ,vol. 4, pp. 893- 902 ,(2016) , 10.1016/S2213-8587(16)30193-0