Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells.
作者： Sung-Kyun Moon , Haa-Yung Lee , Huiqi Pan , Tamotsu Takeshita , Raekil Park
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摘要: Background We recently showed that beta-defensins have antimicrobial activity against nontypeable Haemophilus influenzae (NTHi) and interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new nomenclature Human Genome Organization) in human middle ear epithelial cells via a Src-dependent Raf-MEK1/2-ERK signaling pathway. Based on these observations, we investigated if could release IL-1 upon exposure lysate NTHi this cytokine synergistic effect up-regulation by bacterial components.
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