Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function.

摘要: Lung-volume reduction surgery (LVRS) improves static lung elastic recoil in selected patients with severe chronic obstructive pulmonary disease (COPD). This explains the increase FEV1 many COPD who undergo LVRS, but fails to explain clinical improvement those without changes FEV1. We prospectively evaluated 17 after rehabilitation prior and again at least 3 mo bilateral LVRS done via median sternotomy. In addition function, recoil, walking distance, exercise capacity, we dynamic respiratory muscle (RM) dyspnea. 12 also quantified hyperinflation (end-expiratory end-inspiratory volume [EELV EILV, respectively]). After rose from 26.7 +/- 1.8 39.0 3.7% predicted (p < 0.004), whereas TLC dropped 134.7 4.8 118.3 4.4% 0.0002), RV 239.6 14.8 180.3 8.7% 0.0002). Isowork dyspnea de...