Evidence for the Scarr-Rowe Effect on Genetic Expressivity in a Large U.S. Sample.

摘要: Using the continuous parameter estimation model (CPEM), a large genotyped adult sample of population Wisconsin, USA (the Wisconsin Longitudinal Study) is examined for evidence Scarr-Rowe effect, gene × environment (G×E) interaction that reduces heritability IQ among those with low socioeconomic status (SES). This method allows differential expressivity polygenic scores predictive both educational attainment and (EA3) on phenotype to be directly operationalized throughout full range these variables. Utilizing parental SES factor-weighted composite as measure childhood SES, effect was found, is, genetic EA3 increased increasing (β = 0.08, p 4.71×10-10, df 6,255). The found male female samples separately, β(males) 5.27×10-5, 3,018; β(females) 1.93×10-6, 3,236. effects were furthermore robust removing outlying values log-transforming variable. results are similar produced using more conventional two-way model, predicting log after main effects; however, CPEM greater degrees freedom, thus better powered detect when it small in magnitude (CPEM β 0.05, 6.69×10-5 vs. 0.02, pone-tailed .045, models used).