Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.
作者： Shiro Maeda , Shuichi Tsukada , Akio Kanazawa , Akihiro Sekine , Tatsuhiko Tsunoda
DOI: 10.1007/S10038-005-0253-9
关键词:
摘要: To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2β (TFAP2B) was likely candidate in view of significant association polymorphism this with diabetes. Extensive analysis region identified several variations within TFAP2B were significantly associated [a variable number tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20–2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; ratio=1.60, 1.22–2.09, 1+2093 (A/C); χ2=12.2, P=0.0004; ratio=1.61, 1.23–2.11]. The also observed UK population. These results suggest might be new contribute pathogenesis
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