Molecular basis for resistance to silver cations in Salmonella
作者： Amit Gupta , Kazuaki Matsui , Jeng-Fan Lo , Simon Silver
DOI: 10.1038/5545
关键词:
摘要: Here we report the genetic and proposed molecular basis for silver resistance in pathogenic microorganisms. The silver resistance determinant from a hospital burn ward Salmonella plasmid contains nine open reading frames, arranged in three measured and divergently transcribed RNAs. The resistance determinant encodes a periplasmic silver–specific binding protein (SilE) plus apparently two parallel efflux pumps: one, a P–type ATPase (SilP); the other, a membrane potential–dependent three–polypeptide cation/proton antiporter …
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