Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.
作者： Krishna K Murthi , Susan E Smith , Arthur F Kluge , Gustave Bergnes , Patrick Bureau
DOI: 10.1016/S0960-894X(03)00320-2
关键词:
摘要: An alanine conjugate of a Candida albicans geranylgeranyl transferase I inhibitor was synthesized to facilitate its uptake into the fungal cell. The antifungal activity CaGGTase-Ala is demonstrated. It also shown that affects prenylation endogenous Rho1p, but has no effect on Ras1p.
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