High prevalence and gender bias in distribution of Plasmodium malariae infection in central east-coast India.

摘要: Light microscopy, the mainstay of malaria diagnosis in epidemiologic studies, exhibits limited sensitivity for detecting low level infections and often under-estimates frequency mixed Plasmodium species infections. To overcome these shortcomings we performed PCR method detection identification blood specimens from 242 individuals collected during peak season incidence (July-October). Malaria prevalence was 81.4% 43.4% by microscopy respectively. Moreover, while detected malariae DNA 108 (44.6%), microscopic examination only 20 (8.3%) parasitized with this species. Further data analysis revealed an independent random distribution pattern parasites irrespective age groups (0-5 yrs, chi-square7df=2.77, P>0.95; 6-15 chi-square7df=4.82, P>0.50; >15 chi-square7df=4.4, P>0.70) sexes (for male chi-square7df=2.48, female, chi-square7df=1.85, P>0.95). However, although parasite is sex, females had more P. (P=0.004, OR=2.312, 95% CI=1.3-4.1). Our study demonstrates that Orissa substantially higher P.malariae than previously suspected may be seasonal. A bionomics vector(s) responsible transmission needed to provide information control state.