Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide

摘要: Abstract Suggestions are made for the conduct of chemotherapy trials in patients with cancer. Application principles involved illustrated a comparative study triethylene thiophosphoramide and nitrogen mustard cancer lung breast, melanoma, Hodgkin's disease. Neither drug was appreciably effective which had previously been irradiated or melanoma. In not 30 to 50 per cent reduction tumor size occurred 10 26 patients. disease certain factors limit completeness comparison, but it is possible draw tentative conclusion that thio-TEPA less active than HN2 (in doses used) inducing remissions. The advantages disadvantages this type trial discussed several suggestions improved experimental design.