Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study.
作者： Franco Roviello , Simone Rossi , Daniele Marrelli , Corrado Pedrazzani , Giovanni Corso
DOI: 10.1002/JSO.20566
关键词:
摘要: Background and objectives This study was aimed at evaluating the prognostic significance of number metastatic nodes in early gastric cancer (EGC). Methods In this multicenter retrospective 652 cases resected EGC were analyzed. We searched for lymph node metastases-associated risk factors to identify subsets patients with different prognosis according involved nodes. Results Nodal involvement observed 14.1%. A significant correlation found between presence metastases tumor size (RR 1.34, P = 0.001), submucosal invasion (RR: 3.14, 0.007), Lauren diffuse/mixed type 4.88, 15) even N0 patients. Conclusions confirmed be a factor. view trend lower recurrence when more than 15 retrieved better staging achieved we consider D2 lymphadenectomy treatment choice.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(28)
A M Bunt, J Hermans, V T Smit, C J van de Velde, G J Fleuren, J A Bruijn, Surgical/pathologic-stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. Journal of Clinical Oncology. ,vol. 13, pp. 19- 25 ,(1995) , 10.1200/JCO.1995.13.1.19
A Cuschieri, , S Weeden, J Fielding, J Bancewicz, J Craven, V Joypaul, M Sydes, p Fayers, Patient survival after D-1 and D-2 resections for gastric cancer: long-term results of the MRC randomized surgical trial British Journal of Cancer. ,vol. 79, pp. 1522- 1530 ,(1999) , 10.1038/SJ.BJC.6690243
L Harrison, Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer. Journal of Gastrointestinal Surgery. ,vol. 2, pp. 126- 131 ,(1998) , 10.1016/S1091-255X(98)80002-4
Toshifusa Nakajima, Gastric cancer treatment guidelines in Japan. Gastric Cancer. ,vol. 5, pp. 1- 5 ,(2002) , 10.1007/S101200200000
Yoshio Gunji, Takao Suzuki, Seiji Hori, Hideki Hayashi, Hisahiro Matsubara, Hideaki Shimada, Takenori Ochiai, Prognostic significance of the number of metastatic lymph nodes in early gastric cancer. Digestive Surgery. ,vol. 20, pp. 148- 153 ,(2003) , 10.1159/000069392
Kazuya Kitamura, Toshiharu Yamaguchi, Hiroki Taniguchi, Akeo Hagiwara, Kiyoshi Sawai, Toshio Takahashi, Analysis of lymph node metastasis in early gastric cancer: rationale of limited surgery. Journal of Surgical Oncology. ,vol. 64, pp. 42- 47 ,(1997) , 10.1002/(SICI)1096-9098(199701)64:1<42::AID-JSO9>3.0.CO;2-P
Hitoshi Katai, Kimio Yoshimura, Keiichi Maruyama, Mitsuru Sasako, Takeshi Sano, None, Evaluation of the new International Union Against Cancer TNM staging for gastric carcinoma Cancer. ,vol. 88, pp. 1796- 1800 ,(2000) , 10.1002/(SICI)1097-0142(20000415)88:8<1796::AID-CNCR6>3.0.CO;2-2
Kenjiro Nakamura, Takashi Morisaki, Atsushi Sugitani, Takahiro Ogawa, Akihiko Uchiyama, Naoko Kinukawa, Masao Tanaka, An early gastric carcinoma treatment strategy based on analysis of lymph node metastasis. Cancer. ,vol. 85, pp. 1500- 1505 ,(1999) , 10.1002/(SICI)1097-0142(19990401)85:7<1500::AID-CNCR10>3.0.CO;2-8
Lionel Lim, Michael Michael, G. Bruce Mann, Trevor Leong, Adjuvant Therapy in Gastric Cancer Journal of Clinical Oncology. ,vol. 23, pp. 6220- 6232 ,(2005) , 10.1200/JCO.2005.11.593
S M EVERETT, A T R AXON, Early gastric cancer in Europe Gut. ,vol. 41, pp. 142- 150 ,(1997) , 10.1136/GUT.41.2.142