Enhanced responsiveness of rat isolated aorta to clonidine after removal of the endothelial cells

摘要: With the endothelium present, maximum response of rat isolated aorta to clonidine was much lower than that noradrenaline. Removal enhanced both adrenoceptor agonists and clonidine-induced contraction became almost equal produced by noradrenaline, although it more sensitive inhibition flunarizine nifedipine. These results indicate noradrenaline activate receptors present in endothelial cells these are highly clonidine.