Enhancement of Ca++ Uptake by Lactose in the Rat Small Intestine

摘要: In previous experiments, lactose was shown to increase the absorption of Ca++ by small intestine rat and other mammals. To further investigate mechanism effect, uptake studied in everted gut sac preparations. Gut sacs from ileum were preincubated with or without for 45 minutes, then tissue 45Ca over first 3 minutes measured presence absence lactose. The 160 mM increased initial rate minute 64% compared NaCl control. effect dependent on preincubation medium only not during measurement uptake. Lactose when concentrations ranged 0.1 10 mM. However, magnitude enhancement concentration reduced below When a period parallel no evidence co-transport into found. These data indicated that is interacting directly solution but absorptive cells their permeability Ca++.