作者: Tomoya Fujiwara , Hiroko Yasuda , Yushi Nishimura , Hisanori Nambu , Takayuki Yakura
DOI: 10.1039/C4RA08741K
关键词:
摘要: The synthesis of 10b-fluorinated analogues protubonine A and its 11a-epimer was accomplished using fluorocyclisation tryptophan-containing dipeptides with N-fluoro-2,4,6-trimethylpyridinium triflate to 3a-fluoropyrrolo[2,3-b]indoles as a key step. Acetylation the indole nitrogen following diketopiperazine formation gave 11a-epimer.