Synthesis of 10b-fluorinated analogues of protubonine A and its 11a-epimer via fluorocyclisation of tryptophan-containing dipeptides

作者: Tomoya Fujiwara , Hiroko Yasuda , Yushi Nishimura , Hisanori Nambu , Takayuki Yakura

DOI: 10.1039/C4RA08741K

关键词:

摘要: The synthesis of 10b-fluorinated analogues protubonine A and its 11a-epimer was accomplished using fluorocyclisation tryptophan-containing dipeptides with N-fluoro-2,4,6-trimethylpyridinium triflate to 3a-fluoropyrrolo[2,3-b]indoles as a key step. Acetylation the indole nitrogen following diketopiperazine formation gave 11a-epimer.

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