Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review).

摘要: Nanotechnology for cancer gene therapy is an emerging field. Nucleic acids, polyamine analogues and cytotoxic products of oxidation, generated in situ by enzyme-catalyzed reaction, can be developed nanotechnology-based therapeutics with reduced systemic toxicity improved therapeutic efficacy. acid-based approaches depend on the compac- tion DNA/RNA to nanoparticles are excellent agents condensation nucleic acids nanoparticles. Polyamines amine oxidases found higher levels tumours compared that normal tissues. Therefore, metabolism polyamines spermidine spermine, their diamine precursor, putrescine, targets antineoplastic since these naturally occurring alkylamines essential mamma- lian cell growth. Intracellular concentrations maintained at a type-specific set point through coordinated highly regulated interplay between biosyn- thesis, transport, catabolism. In particular, catabolism involves copper-containing oxidases. Several studies showed important role enzymes developmental disease-related processes animals control homeostasis response cellular signals, drug treatment, environmental and/or stress. The production toxic aldehydes reactive oxygen species (ROS), H2O2 suggests mechanism which exploited as targets. combination bovine serum oxidase (BSAO) prevents tumour growth, particularly well if enzyme has been conjugated biocompatible hydrogel polymer. findings described herein suggest enzymatically formed activate stress signal transduction pathways, leading apoptotic death. Consequently, superparamag- netic or other advanced nanosystem based directed acid assemblies, polyamine-induced DNA condensation, may proposed futuristic anticancer utilizing BSAO. BSAO employed generation metabolites.