Alloreactive lymphoid infiltrates in human heart transplants. Loss of class II-directed cytotoxicity more than 3 months after transplantation.
作者： A.J. Ouwehand , L.M.B. Vaessen , C.C. Baan , N.H.P.M. Jutte , A.H.M.M. Balk
DOI: 10.1016/0198-8859(91)90071-G
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摘要: From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated found among from without myocytolysis. In first 3 months post 57% showed cytotoxicity against both class I II mismatched donor major histocompatibility complex (MHC) antigens, changing to an incidence 33% greater than 90 days. This proved due a significant decrease number with human leukocyte antigen II-directed cytotoxicity. study shows that early after transplantation is infiltrated activated donor-specific cytotoxic cells which recognize broad spectrum MHC this becomes more restricted.
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