Impact of optic flow perception and egocentric coordinates on veering in Parkinson's disease

摘要: Spatial navigation is a complex process requiring integration of visuoperceptual information. The present study examined how visuospatial function relates to navigational veering in Parkinson's disease, movement disorder which cognition affected by the degeneration basal ganglia and resulting dysfunction parietal lobes. We hypothesized that patients whose initial motor symptoms start on left versus right side body (LPD, predominant right-hemisphere dysfunction; RPD, left-hemisphere dysfunction) would display distinct patterns associated with groups’ dissimilar profiles. Of particular interest was examine association (lateral deviation along medio-lateral axis) perception egocentric coordinates radial optic flow patterns, both are mediated Thirty-one non-demented disease (16 LPD, 15 RPD) 18 healthy control (HC) adults received tests, whom 23 17 HC also underwent assessment. participants were three visual-feedback conditions: none (eyes closed), natural, supplied virtual-reality headset. All groups veered when walking eyes closed, women more so than other participants. On assessments visual feedback, only LPD deviated centre. tests function, perceived midline shifted rightward (men women), increasingly addition input. In contrast, men RPD showed leftward deviation. hemifield as faster hemifield, trend for opposite pattern LPD. Navigational not speed asymmetries, it dependence, though fact subjects visually dependent those RPD. Our results indicate (i) parietal-mediated space symptom onset gender affecting spatial performance, (ii) input affects veering.