MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
作者： Kasey C. Vickers , Brian T. Palmisano , Bassem M. Shoucri , Robert D. Shamburek , Alan T. Remaley
DOI: 10.1038/NCB2210
关键词:
摘要: Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Cellular export of miRNAs to HDL was demonstrated to be regulated by neutral sphingomyelinase. Reconstituted HDL injected into mice retrieved distinct miRNA profiles from normal and atherogenic models. HDL delivery of both exogenous and endogenous …
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ucsf.edu 参考文章(62)
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