The Discovery of Viruses and the Evolution of Vaccinology

摘要: The early part of the twentieth century produced significantly fewer major advances in vaccinology than had latter previous century. However, beginning with landmark work German physician Robert Koch, who 1876 definitively demonstrated transmissible nature Bacillus anthracis, both periods witnessed a number important scientific that would serve to build firm foundation for future vaccines. As described Chaps. 4 and 5, Louis Pasteur extended Koch formalize concept microbial attenuation, leading directly his audacious experiments live, attenuated anthrax vaccine livestock rabies humans.